Important Notes

Contraindications: Avoid use in patients using serotonin agonists such as SSRI or SSNI medications.

Works synergistically with activated B complex formulas and NAD+

5 Hydroxy Tryptophan: Supporting Conditions

5 Hydroxy Tryptophan, when prescribed appropriately, may aid patients dealing with various conditions. This statement doesn’t assert a cure for these disorders. Usage should rely on published scientific and clinical data for each condition and work with your healthcare professional for best results.

Alcoholism or alcohol withdrawal
Amphetamine intake
Appetite suppression
Excessive coughing
Lesch-Nyhan syndrome
Migraine prophylaxis
Weight loss programs

Facilitated Functions:

Acts as a precursor for Serotonin synthesis.

Understanding 5 Hydroxy Tryptophan (5-HTP):

5-HTP, a transitional chemical in serotonin synthesis, primarily affects the brain. It regulates appetite, induces sleep, and exhibits antidepressant effects. This compound easily crosses the blood-brain barrier, influencing the serotonergic nervous system.

Research in 1971 linked tryptophan intake to serotonin production, essential for various neurotransmitters. Tryptophan metabolism relies on hydroxylase, needing pyridoxine and magnesium as catalysts.

5-HTP and Various Conditions:

  • Amino acids in psychiatry: Research continues to explore the role of amino acids in mental health. Amino acids serve as building blocks for neurotransmitters, and their balance can impact mood, cognition, and mental health conditions.

  • Serotonin receptors and mental health: Serotonin receptors still play a crucial role in mental health, affecting sleep, anxiety disorders, and depression. Understanding how these receptors function is vital for developing treatments targeting these conditions.

  • Brain serotonin, obesity, and depression: The relationship between brain serotonin levels, carbohydrate craving, obesity, and depression remains an area of interest in research. Serotonin’s involvement in these areas suggests its potential impact on both mental health and metabolic disorders.

  • Serotonin and depression: Studies continue to investigate the link between serotonin and depression. Tryptophan depletion in depressed patients has been studied to understand how serotonin levels affect mood.

  • Tryptophan depletion and mood: The mood-lowering effect of tryptophan depletion, especially in individuals at genetic risk for major affective disorders, remains a topic of study in understanding depression and related conditions.

  • Neuroendocrine response in depression: Research exploring the neuroendocrine response to challenges like L-5-Hydroxytryptophan in depression contributes to understanding the underlying mechanisms of depressive disorders.

  • 5-Hydroxytryptophan in obese subjects: The use of 5-Hydroxytryptophan in obese adults, its impact on eating behavior, and adherence to dietary prescriptions continue to be studied in the context of weight management.

Addiction and Pain: 5-HTP influences the brain’s pain modulation area, crucial for serotonin function. Decreased serotonin levels during withdrawal lead to heightened pain sensitivity. Studies have shown improvement in fibromyalgia with 5-HTP treatment.

Migraines: Serotonergic activity closely relates to migraines; 5-HTP shows promise in preventing these headaches.

Sleep: Taken before bedtime, 5-HTP can induce sleep by aiding melatonin production.

Depression and Anxiety: Useful in specific types of depression, 5-HTP aids neurotransmission. It also mitigates anxiety by enhancing serotonin availability.

Other Applications:

Aggressive Behavior:
Tryptophan and serotonin might inhibit aggressive behavior.

Appetite Suppressant:
5-HTP, by increasing serotonin, can act as an appetite suppressant, aiding weight loss.

Excessive Coughing: Studies suggest 5-HTP can modulate the cough reflex.

Interactions and Conclusion:

Vitamin-amino acid interactions, especially with pyridoxine, are crucial in amino acid metabolism. Studies on 5-HTP suggest no toxicity at varying doses, although high doses might induce drowsiness.

Notes of Interest
Queensland police were finding 5HTP when raiding dealers of the drug ecstasy / MDMA which lead to its ban. Preloading and postloading were reported through the consumption of supplements (5-HTP). Banning this substance shows the Queensland government to be incompetent in their understanding of what is a dangerous drug. 5HTP is in every human brain because it is the essential biosynthetic pathway from tryptophan to the neurotransmitter serotonin. The body can’t make serotonin any other way. 5HTP was later returned to the natural health market in capsules 100mg or less.

Serotonin Pathway diagram

References available on request