The anti ageing big guns.
The original study that inspired global excitement about the use of Carbon 60 Olive Oil: Almost Double Lifespan.
“Abstract: Countless studies showed that fullerene (C60) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C60 has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C60 and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C60 dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C60-olive oil solutions in an experimental model of CCl4 intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C60 is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C60 including cancer therapy, neurodegenerative disorders, and ageing.”
Full study available for rent or purchase here: http://www.sciencedirect.com/science/article/pii/S0142961212003237
Charts associated with this study are linked below. Authors of the above paper have issued several corrections, most notably a correction to the survival chart, figure 3. These charts reflect the corrected data: http://www.sciencedirect.com/science/article/pii/S0142961212005522
Fasting & Exercise
Longevity genes are turned on by fasting and intense exercise. Taking exercise to the level where you have raised the heart rate and been out of breath daily or every other day is linked to a reduction in different diseases—certainly heart disease. Short, high intensity interval training seems to be almost as good (and more convenient) as longer exercise . And the worst thing you can do [for aging] is to be sedentary. We recommend periodic fasting, during fasting, cells undergo an adaptive stress response that may account for its many beneficial effects. Alternate-day fasting improves markers of oxidative stress, a measure of longevity. Intermittent fasting has shown to protect against many age-related diseases including diabetes and cardiovascular disease and is seen as a ‘digestive reset’.
Eating organic foods free from pesticides is strongly correlated with a dramatic reduction in the risk of cancer, according to a groundbreaking study published in an American Medical Association journal. Research Study Here. It’s ethically better for all systems of nature.
Research shows that polyphenols like Resveratrol have displayed anti-aging properties and even increased the lifespans of some organisms. While this effect on humans requires a bit more research before it can be confirmed as fact, Resveratrol seems to have the ability to activate certain genes that prevent the effects of aging from manifesting as rapidly as usual. It is likely that we see a decrease in cancer risk with polyphenol consumption especially cancers that develop with genomic instability, as well as lifespan extension.
Nicotinamide riboside (NR) & Nicotinamide adenine dinucleotide (NAD+)
Nicotinamide riboside (NR) supports the multiple functions of cellular mitochondria, helping to regulate cellular aging and providing positive support for metabolic syndrome.
Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on life span. As such, the use of NAD+ precursors to augment NAD+ bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans.
It is NADH, which captures the electron “sparks” thrown off during Krebs’ cycle oxidation and shuttles them to the electron transport side chain energy production cycle. Each unit of NADH is capable of generating three units of ATP energy. In a very real sense, NADH is the “energy of life” coenzyme. If you take look at the Citric Acid Cycle you will see the many important reactions NADH is involved in.
Cold Exposure & Sauna
Research on rats in shallow, cool water for four hours per day showed that rats burned so many extra calories that they ate 50% more than control rats. The cold-exposed rats still weighed less than the control rats and lived 10% longer.
Another study lowered the core temperature of mice by 0.3 °C (males) and 0.34 °C (females), resulting in an increase in the average lifespan of 12 and 20% respectively.
Increased longevity via cold-exposure could be due to hormesis. Hormesis refers to the paradoxical adaptation that makes animals stronger and more efficient if they are exposed to environmental stresses
Other researchers prefer the theory that lower temperature promotes longevity by slowing down the rate of reaction of various metabolic processes. This means fewer by-products of metabolism, such as reactive oxygen species. But this does not explain the benefits of sauna use.
Alternatively, increased longevity from cold exposure may be due to a modulation of genes, such as TRPA-1 and DAF-16 .
Other research says that sauna use 2-3 times a week is associated with a 23% decrease in fatal cardiovascular incidents while sauna use 4-7 times a week is associated with a 48% decrease in fatal cardiovascular incidents.
More human research is needed to examine the anti-aging effects of cold exposure in humans
Traditionally used for gastrointestinal symptoms, berberine has emerged as a potent cardiometabolic aid with diverse benefits and mechanisms of action.
It has hypoglycemic effects, via both an inhibition of alpha-glucosidase activity and an upregulation of insulin receptors in peripheral tissues, thereby improving insulin sensitivity as well as having anti-inflammatory properties. Poor blood sugar regulation and cardiovascular health contribute to major health diseases that shorten lifespan.
This study on Berberine concludes that…
Quality sleep us under stress from the modern world. Being removed from nature with lack of morning sunlight and artificial light at night.
We advocate working towards being a better person that you were yesterday, having the courage to face your fears and triggers, having the humility and responsibility to make changes. We aim to get better at the following… the attributes are like a Yin and Yang of chakras.